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Updated: Aug 29, 2026

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
Published on: October 2, 2014
Coupling apoptosis resistance to the cellular stress response: the IAP-Hsp90 connection in cancer
1Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, 364 Plantation Street, LRB-428, Worcester, Massachusetts 01605, USA. dario.altieri@umassmed.edu
Abstract:
Understanding how tumor cells manage to survive and proliferate in ever-changing and often harmful microenvironments is a daunting challenge in tumor biology, and a major cause of treatment failure in the oncology clinic. Recent data have now demonstrated a direct link between the molecular chaperone Hsp90 and survivin, a dual regulator of cell proliferation and cell death over-expressed in virtually every human tumor. While the survivin-Hsp90 association may help tumor cells elevate their anti-apoptotic threshold and promote their proliferation, it may also provide new opportunities for rational cancer therapy.
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