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Related Experiment Videos

Pregnancy rate in an oocyte donation program.

F Zegers-Hochschild1, E Fernández, C Fabres

  • 1Unit of Reproductive Medicine, Clinica Las Condes Hospital, Santiago, Chile.

Journal of Assisted Reproduction and Genetics
|August 1, 1992
PubMed
Summary
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Oocyte donation offers a successful treatment for infertility due to ovarian issues. A simple hormone therapy regimen resulted in a high pregnancy rate per embryo transfer.

Area of Science:

  • Reproductive Endocrinology
  • Infertility Treatment
  • Assisted Reproductive Technology

Background:

  • Oocyte donation is a viable option for women experiencing ovarian failure or dysfunction.
  • Assisted reproductive technologies aim to overcome infertility challenges.

Purpose of the Study:

  • To evaluate the efficacy of a fixed and simple hormonal replacement therapy in oocyte donation programs.
  • To determine the pregnancy rate per embryo transfer in women undergoing oocyte donation.

Main Methods:

  • Seventeen cycles of in vitro fertilization and embryo transfer using donated oocytes were performed in 13 women.
  • Hormonal replacement therapy involved oral estradiol valerate (6 mg daily) and intramuscular progesterone in oil (100 mg daily).
  • Hormone therapy was continued for 10 weeks post-embryo transfer in cases of established pregnancy.

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Main Results:

  • A total of 13 embryo transfers were performed, resulting in 8 pregnancies.
  • The pregnancy rate per transfer was 61.5%.
  • Seven of the eight pregnancies were progressing normally, including one twin gestation.

Conclusions:

  • A fixed and simple hormonal replacement therapy regimen is effective in oocyte donation programs.
  • Oocyte donation with this protocol provides an adequate treatment option for infertile couples with ovarian dysfunction.
  • The program demonstrated a high success rate, offering hope for successful pregnancies.