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Related Experiment Videos

How do Abl family kinases regulate cell shape and movement?

Samuel E Hernández1, Maithreyi Krishnaswami, Ann L Miller

  • 1Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA.

Trends in Cell Biology
|January 20, 2004
PubMed
Summary

Abl family kinases are crucial for cell shape and movement by controlling the cytoskeleton. These nonreceptor tyrosine kinases directly organize cellular structure, impacting cell motility and morphogenesis.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Abl family nonreceptor tyrosine kinases regulate cell morphogenesis and motility.
  • These kinases, including Drosophila (D-) Abl and vertebrate Abl and Arg proteins, relay signals from cell surface receptors.
  • They are involved in cytoskeletal rearrangements.

Purpose of the Study:

  • To elucidate the mechanisms by which growth-factor and adhesion receptors regulate Abl family kinase activity.
  • To understand how activated Abl family kinases regulate cytoskeletal dynamics.
  • To explore the direct role of Abl family kinases in organizing cytoskeletal structure.

Main Methods:

  • Genetic analysis of normal and leukemia cells.
  • Biochemical analyses.

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  • Crystallographic analyses.

    • Main Results:

    • Abl family kinases phosphorylate cytoskeletal regulatory proteins upon activation.
    • The C-terminal domains of Abl family kinases bind to cytoskeletal components.
    • Emerging evidence indicates direct in vivo organization of cytoskeletal structure by these kinases.

    Conclusions:

    • Abl family kinases are key regulators of cell shape and movement.
    • They act as signal transducers linking cell surface receptors to cytoskeletal dynamics.
    • These kinases possess domains for direct cytoskeletal organization, influencing cell structure in vivo.