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Zeta potential determination by streaming current modelization and measurement in electrophoretic microfluidic
Louis Renaud1, Pascal Kleimann, Pierre Morin
1Laboratoire d'Electronique Nanotechnologies Capteurs (LENAC), Université Claude Bernard Lyon 1, Villeurbanne, France. louis.renaud@lenac.univ-lyon1.fr
Electrophoresis
|January 20, 2004
Summary
We developed a fast, low-cost method to measure zeta-potential by modeling streaming currents in microfluidic devices. This technique improves surface charge quantification for enhanced separation performance in analytical chemistry.
Area of Science:
- Analytical Chemistry
- Surface Science
- Microfluidics
Background:
- Capillary and microfluidic electrophoresis are sensitive to surface phenomena affecting separation.
- Improved surface functionalization is needed to enhance performance.
- Accurate quantification of surface charges at liquid/solid interfaces is crucial.
Purpose of the Study:
- To present a fast, simple, and low-cost technique for zeta-potential measurement.
- To enable accurate quantification of surface charges.
- To improve separation performances in microfluidic systems.
Main Methods:
- Modeling and measurement of streaming currents.
- Microfluidic simulations using Navier-Stokes equations.
- Charge repartition simulations using Poisson-Boltzmann equation.
Main Results:
- The streaming current modelization is simplified in microfluidic devices.
- The method was validated using fused-silica capillaries with square and circular cross sections.
- The technique is easily adaptable to various lab-on-chip microsystems.
Conclusions:
- The developed technique offers a fast and accurate way to measure zeta-potential.
- This method addresses the need for improved surface charge quantification.
- The approach has broad applicability in microfluidic analytical systems.
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