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The plasma membrane calcium pump: a multiregulated transporter.
K K Wang1, A Villalobo, B D Roufogalis
1Department of Pharmacology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA.
Trends in Cell Biology
|February 1, 1992
Summary
Cellular calcium (Ca2+) transients are regulated by the plasma membrane calcium pump. This review details the pump's structure, function, and diverse regulatory mechanisms, highlighting their physiological importance.
Area of Science:
- Biochemistry
- Cell Biology
- Physiology
Background:
- Cellular activation triggers calcium (Ca2+) transients, crucial for cell signaling.
- The plasma membrane calcium pump actively extrudes Ca2+, influencing these transients.
- Understanding Ca2+ pump regulation is key to cell function.
Purpose of the Study:
- To review the regulatory mechanisms of the plasma membrane Ca2+-pump.
- To explore the relationship between Ca2+-pump structure and function.
- To discuss the physiological significance of Ca2+-pump regulation.
Main Methods:
- Literature review of molecular cloning and functional studies.
- Analysis of regulatory interactions (calmodulin, phospholipids, kinases).
- Examination of gene expression and isoform diversity.
Main Results:
- Molecular cloning elucidated the Ca2+-pump's structure-function relationship.
- Multiple regulators (calmodulin, phospholipids, kinases) modulate pump activity.
- Gene expression and distinct isoforms offer long-term control and functional diversity.
Conclusions:
- The Ca2+-pump is a key regulator of intracellular calcium homeostasis.
- Diverse regulatory mechanisms ensure precise control of Ca2+ transients.
- Understanding these mechanisms is vital for comprehending cellular physiology.