Related Experiment Video
Updated: Aug 12, 2026
07:47
Microscopy of Fission Yeast Sexual Lifecycle
Published on: March 9, 2016
Cold fission: splitting the pombe cell at room temperature
1Unité Recherches sur le cycle cellulaire, Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland.
Trends in Cell Biology
|March 1, 1994
Summary
Genetic studies in fission yeast are revealing key mechanisms of cytokinesis, the process of cell division. Research identifies genes essential for septum formation and its coordination with mitosis.
Area of Science:
- Cell Biology
- Genetics
- Molecular Biology
Background:
- Cytokinesis, the final stage of cell division, and its cell cycle coordination remain incompletely understood.
- Fission yeast serves as a model organism for genetic studies of fundamental cellular processes.
Purpose of the Study:
- To investigate the genetic basis of cytokinesis in fission yeast.
- To identify genes involved in septum formation and its regulation.
Main Methods:
- Isolation and characterization of conditional fission yeast mutants with defects in cytokinesis.
- Cloning of genes affected in these mutants.
Main Results:
- Identification of several conditional mutants exhibiting defective septum formation during cytokinesis.
- Initiation of gene cloning efforts to elucidate the molecular components of the division septum.
Conclusions:
- Genetic analysis of fission yeast mutants is crucial for understanding cytokinesis.
- The identified genes are expected to reveal mechanisms controlling septum construction and its cell cycle timing.
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