Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pores for thought: nuclear pore complex proteins.

M P Rout1, S R Wente

  • 1Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.

Trends in Cell Biology
|October 1, 1994
PubMed
Summary

Nuclear pore complexes (NPCs) facilitate nuclear-cytoplasmic transport. Recent discoveries identify new NPC proteins, revealing their roles in NPC filaments and enabling a deeper understanding of this essential organelle.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mechanism of nucleocytoplasmic transport through the nuclear pore complex.

Cold Spring Harbor symposia on quantitative biology·2011
Same author

Pore relations: nuclear pore complexes and nucleocytoplasmic exchange.

Essays in biochemistry·2002
Same author

Nuclear transport: never-ending cycles of signals and receptors.

Essays in biochemistry·2002
Same author

Isolation and characterization of subnuclear compartments from Trypanosoma brucei. Identification of a major repetitive nuclear lamina component.

The Journal of biological chemistry·2001
Same author

Nup2p dynamically associates with the distal regions of the yeast nuclear pore complex.

The Journal of cell biology·2001
Same author

Phosphorylation regulates the interaction between Gln3p and the nuclear import factor Srp1p.

The Journal of biological chemistry·2001

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Structural Biology

Background:

  • Nuclear pore complexes (NPCs) are vital for regulating transport between the nucleus and cytoplasm.
  • NPCs are massive protein assemblies crucial for cellular function.

Purpose of the Study:

  • To summarize recent findings on identified NPC polypeptides.
  • To understand the association of NPC proteins within the complex.

Main Methods:

  • Biochemical studies
  • Structural analyses
  • Genetic investigations

Main Results:

  • Numerous NPC polypeptides have been identified, many with novel sequences.
  • Several identified proteins form extended cytoplasmic and nucleoplasmic NPC filaments.

Related Experiment Videos

  • Initial biochemical, structural, and genetic data are emerging.

    • Conclusions:

    • The identification of new NPC proteins is advancing our understanding of NPC structure and function.
    • Ongoing studies are beginning to elucidate how these proteins assemble into a functional organelle.