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Control of SV40 DNA replication by protein phosphorylation: a model for cellular DNA replication?

E Fanning1

  • 1Institute for Biochemistry, Karlstrasse 23, 80333 Munich, Germany.

Trends in Cell Biology
|July 1, 1994
PubMed

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DNA Damage Can Stall the Cell Cycle02:36

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of replication.