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Updated: Aug 29, 2026

Visualizing Clathrin-mediated Endocytosis of G Protein-coupled Receptors at Single-event Resolution via TIRF Microscopy
Published on: October 20, 2014
Are caveolae involved in clathrin-independent endocytosis?
B van Deurs1, P K Holm, K Sandvig
1Structure Cell Biology Unit, Department of Anatomy, the Panum Institute, University of Copenhagen, Denmark.
Abstract:
In addition to endocytosing molecules via clathrin-coated pits, cells also internalize membrane and fluid by a clathrin-independent endocytic mechanism. In this article we search for the equivalent of clathrin-coated pits in clathrin-independent endocytosis, and discuss some pitfalls in the interpretation of electron micrographs. We also discuss how the early steps in clathrin-independent endocytosis might be analysed morphologically, and we argue that caveolae are not involved in clathrin-independent endocytosis.
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