Transcriptional regulation by the retinoblastoma protein

The retinoblastoma protein (RB) plays a key role in the control of cell proliferation and mediates the terminal differentiation of certain cell types. Increasing evidence suggests that RB functions by contacting and modifying the behaviour of transcription factors. RB can form complexes with E2F and MyoD in vivo, and complexes with a number of other transcription factors have also been demonstrated in vitro. The interaction of regulatory transcription factors with RB may be explained by sequence similarity between RB and two general transcription factors: TBP and TFIIB. Here I review the evidence for a role of RB in the regulation of transcription and highlight some of the likely mechanisms of RB function.