Early events in eukaryotic DNA replication
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Updated: Aug 9, 2026

Visualization of DNA Replication in the Vertebrate Model System DT40 using the DNA Fiber Technique
Published on: October 27, 2011
1Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK EN6 3LD.
Abstract:
Eukaryotic DNA replication is a tightly regulated process that occurs during a discrete period of the cell cycle known as S phase. Recent work in two different systems has identified key participants in this process and characterized many of the protein-protein interactions required for the establishment of functional replication complexes. From these results, an understanding of how the control of DNA replication is exercised during the cell cycle appears to be on the horizon.
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