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Related Experiment Videos

Laminin receptors: achieving specificity through cooperation.

A M Mercurio1

  • 1Laboratory of Cancer Biology, Deaconess Hospital and Harvard Medical School, 50 Binney St, Boston, MA 02115, USA.

Trends in Cell Biology
|November 1, 1995
PubMed
Summary

Laminin receptors link extracellular matrix proteins to cell signaling pathways. This review explores how these receptors recognize laminin structures and transmit signals, influencing development and disease.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Developmental Biology

Background:

  • Laminins are crucial extracellular matrix proteins impacting cellular processes.
  • Their biological effects are transmitted via surface receptors to intracellular pathways.
  • Diverse phenomena suggest cooperative receptor action for laminin specificity.

Purpose of the Study:

  • To review current knowledge of laminin receptors.
  • To discuss how receptors distinguish between different laminins.
  • To explore signal relay mechanisms from laminin to cell.

Main Methods:

  • Literature review of laminin receptor research.
  • Analysis of structural and functional data on laminin-receptor interactions.
  • Synthesis of current understanding of signaling pathways.

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Main Results:

  • Laminin receptors, including integrins, mediate laminin's biological effects.
  • Receptors link the extracellular matrix to intracellular signaling.
  • Cooperation among receptor classes provides specificity.

Conclusions:

  • Understanding laminin receptors is key to deciphering laminin functions.
  • Receptor mechanisms for recognizing laminin structural diversity are critical.
  • Further research can elucidate signaling pathways for therapeutic targets.