Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Flippases.

A K Menon1

  • 1Dept of Biochemistry, University of Wisconsin-Madison, 420 Henry Mall, Madison, WI 53705, USA.

Trends in Cell Biology
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Cell membrane biogenesis relies on phospholipid and glycolipid flipping, a process accelerated by protein catalysts called flippases. Recent research has identified two key flippases in animal cell plasma membranes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Basic echocardiography for undergraduate students: a comparison of different peer-teaching approaches.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2017
Same author

Lipid flippases and their biological functions.

Cellular and molecular life sciences : CMLS·2006
Same author

Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast.

Biochemical Society transactions·2006
Same author

The DXD motif is required for GM2 synthase activity but is not critical for nucleotide binding.

Glycobiology·2001
Same author

Endoplasmic reticulum proteins involved in glycosylphosphatidylinositol-anchor attachment: photocrosslinking studies in a cell-free system.

European journal of biochemistry·2001
Same author

Aortico-pulmonary paraganglioma associated with bilateral carotid body tumors. Diagnostic presentation and clinical implications.

The Journal of cardiovascular surgery·2001
Same journal

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Trends in cell biology·2026
Same journal

Spindle errors: A stress test for epithelial robustness.

Trends in cell biology·2026
Same journal

Multicellular ecosystems: Linking cellular diversity to tissue function and disease.

Trends in cell biology·2026
Same journal

Orchestrating the signaling-bias at the protease-activated receptor, PAR1.

Trends in cell biology·2026
Same journal

Crashing by design: Utilizing DNA damage for MCC differentiation.

Trends in cell biology·2026
Same journal

The value of a shared lab: Our insights.

Trends in cell biology·2026
See all related articles

Area of Science:

  • Biochemistry
  • Cell Biology
  • Membrane Biology

Background:

  • Transbilayer lipid movement is crucial for cellular membrane biogenesis.
  • Phospholipid and glycolipid flipping creates functional lipid asymmetry.
  • This flipping is slow in artificial membranes but rapid in biomembranes.

Purpose of the Study:

  • To review current knowledge on protein catalysts (flippases) involved in membrane lipid translocation.
  • To highlight recent advancements in the isolation of flippases.

Main Methods:

  • Literature review of existing data on flippases.
  • Analysis of recent experimental findings on flippase isolation.

Main Results:

  • Flipping of lipids across cellular membranes is essential for membrane function.

Related Experiment Videos

  • Protein catalysts, termed flippases, accelerate lipid translocation.
  • Two flippases recently isolated operate at the plasma membrane of animal cells.

    • Conclusions:

    • Flippases are critical for achieving biologically relevant rates of lipid flipping.
    • The identification of specific flippases provides new insights into membrane dynamics.
    • Further research into flippase mechanisms will advance our understanding of cellular membranes.