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Updated: May 2, 2026
Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
Published on: July 25, 2014
[Study on tumor necrosis factor-alpha and interleukin 2 in rat skin allograft]
Junlin Wang1, Yan Jin, Xiaoliang Liu
1Department of Oral Histology and Pathology, College of Stomatology, Fourth Military Medical University, Xi'an 710032, China.
Objective:
To elucidate the histocompatibility of tissue engineered rat skin through studying the effect of TNF-alpha and IL-2 in immunological rejection after rat skin allograft.
Methods:
Tissue engineered skin that the basic materials were taken from neonatal SD rats was cultured in lab, grafted to adult Wistar rats. The expressions of TNF-alpha and IL-2 in grafted tissue were detected with immunohistochemical staining and Western blot.
Results:
The expressions of TNF-alpha and IL-2 were remarkable in skin allograft group, but low in tissue engineered skin group.
Conclusion:
The expressions of TNF-alpha and IL-2 and the immunological rejection were closely related after skin allograft, but the tissue engineered skin has favorable histocompatibility and doesn't arose obvious immunological rejections.
