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SARS: lessons learned from other coronaviruses.

Sonia Navas-Martin1, Susan R Weiss

  • 1Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.

Viral Immunology
|January 22, 2004
PubMed
Summary
This summary is machine-generated.

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Severe acute respiratory syndrome (SARS) coronaviruses are emerging pathogens. This review covers coronavirus molecular biology and pathogenesis, focusing on mouse hepatitis virus (MHV) as a model for human demyelinating diseases.

Area of Science:

  • Virology
  • Pathogenesis
  • Molecular Biology

Background:

  • The emergence of SARS-associated coronavirus has renewed interest in coronavirus research.
  • Coronaviruses are a significant group of viruses with diverse pathogenic potentials.
  • Mouse hepatitis virus (MHV) serves as a crucial model for studying coronavirus infections and related diseases.

Purpose of the Study:

  • To review the current understanding of coronavirus molecular biology and pathogenesis.
  • To highlight the importance of MHV as a model system for studying demyelinating diseases.
  • To emphasize the need to leverage existing coronavirus research for future SARS studies.

Main Methods:

  • Literature review of existing research on coronaviruses.
  • Focus on studies detailing the molecular biology of coronaviruses.

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  • Emphasis on pathogenesis research, particularly using MHV models.

    • Main Results:

    • Coronaviruses exhibit complex molecular biology and pathogenesis.
    • MHV infection in mice provides valuable insights into demyelinating diseases like multiple sclerosis.
    • Coronaviruses are recognized as emerging pathogens with significant public health implications.

    Conclusions:

    • Decades of coronavirus research provide a foundation for understanding SARS.
    • Continued investigation into coronavirus molecular biology and pathogenesis is essential.
    • MHV remains a vital model for advancing research on coronavirus-induced diseases and neurological conditions.