Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclic AMP signaling in Cryptococcus neoformans.

Read Pukkila-Worley1, J Andrew Alspaugh

  • 1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

FEMS Yeast Research
|January 22, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cysteine-rich domain of the <i>Cryptococcus neoforman</i>s Cuf1 transcription factor is required for high copper stress sensing and fungal virulence.

mBio·2026
Same author

Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling.

eLife·2026
Same author

<i>kri-1/KRIT1</i> restrains <i>skn-1/NRF2</i> activation to promote innate immune and lipid homeostasis.

bioRxiv : the preprint server for biology·2026
Same author

Interaction between Rsp5-dependent ubiquitination and trehalose production during <i>Cryptococcus neoformans</i> temperature stress adaptation.

mSphere·2026
Same author

Regulation of trehalose biosynthesis and thermotolerance by the <i>Cryptococcus neoformans</i> HECT E3 ubiquitin ligase Rsp5.

bioRxiv : the preprint server for biology·2026
Same author

Cryptococcus: Emerging host risk factors for infection.

PLoS pathogens·2025
Same journal

Yeasts in the Gastrointestinal Tract.

FEMS yeast research·2026
Same journal

Nutrient sensing and transceptor-mediated metabolic control in yeast.

FEMS yeast research·2026
Same journal

Establishment of a Protoplast Transformation Method in the Oleaginous Yeast Rhodotorula toruloides.

FEMS yeast research·2026
Same journal

The oxidative cost of losing low temperature viability protein 1 [Ltv1]: insights into cellular damage and homeostasis.

FEMS yeast research·2026
Same journal

Systems biology of yeast metabolism.

FEMS yeast research·2026
Same journal

Uncorking wine yeast genomics from grape to glass.

FEMS yeast research·2026
See all related articles

Pathogenic fungi sense host signals using cell surface proteins to activate the cyclic adenosine monophosphate (cAMP) pathway. This pathway regulates fungal differentiation and virulence during infection.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Mycology

Background:

  • Pathogenic microorganisms must adapt to host environments to survive infections.
  • Cell surface proteins and signal transduction pathways are crucial for pathogen adaptation.
  • The cyclic adenosine monophosphate (cAMP) pathway is a conserved signaling mechanism in many organisms.

Purpose of the Study:

  • To review how pathogenic fungi utilize the cAMP signal transduction pathway.
  • To explore the role of cAMP in regulating fungal cellular differentiation.
  • To understand the impact of cAMP on fungal virulence potential.

Main Methods:

  • Review of existing literature on microbial signal transduction.
  • Analysis of the cAMP pathway in pathogenic fungi.

Related Experiment Videos

  • Examination of gene expression alterations in response to host signals.

    • Main Results:

    • Pathogen cell surface proteins detect host signals.
    • Signal transduction cascades, including the cAMP pathway, are activated.
    • Altered gene expression leads to adaptive cellular responses, including differentiation and virulence.

    Conclusions:

    • The cAMP pathway is a key regulator of cellular differentiation in pathogenic fungi.
    • This pathway significantly influences the virulence potential of fungi.
    • Understanding cAMP signaling is vital for developing strategies against fungal infections.