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Symptoms and signs have changed in Swedish children with coeliac disease

Jonas F Ludvigsson1, Pär Ansved, Karin Fälth-Magnusson

  • 1Department of Paediatrics, Orebro University Hospital, Orebro, Sweden. jonasludvigsson@yahoo.com

Journal of Pediatric Gastroenterology and Nutrition
|January 22, 2004
PubMed

Insights

The clinical presentation of pediatric coeliac disease has shifted over the past decade, coinciding with declining incidence rates. Symptoms like abdominal distension and irritability are now more common in children with coeliac disease.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Epidemiology

Background:

  • Coeliac disease incidence in children has been declining over the past decade.
  • Understanding the evolving clinical presentation is crucial for timely diagnosis.

Purpose of the Study:

  • To investigate changes in the symptoms and signs of coeliac disease in children.
  • To determine if the clinical picture at disease onset has altered alongside decreasing incidence.

Main Methods:

  • A comparative study involving children with biopsy-confirmed coeliac disease (n=79) and controls (contemporary n=43, historic n=65).
  • Data collected from eight pediatric departments in Southeast Sweden as part of the ABIS study.
  • Symptoms were recorded using a standardized form.

Main Results:

  • Children with coeliac disease exhibited higher rates of abdominal distension (OR=22.17), thin extremities (OR=5.89), irritability (OR=6.50), and tiredness (OR=15.43) compared to controls.
  • Compared to historical cohorts with higher incidence, younger children diagnosed recently showed fewer instances of diarrhea (OR=0.23), suboptimal weight gain (OR=0.02), and linear growth issues (OR=0.14).

Conclusions:

  • The clinical features of coeliac disease in young children have evolved over the last 10 years.
  • These changes in presentation are occurring in parallel with shifts in disease incidence.
Abstract

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