Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epileptic encephalopathies: a brief overview.

Rima Nabbout1, Olivier Dulac

  • 1Department of Pediatrics, Hôpital Necker Enfants Malades, 149 Rue de Sèvres, 75743 Paris cedex 15, France. rimanabbout@yahoo.com

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|January 22, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling sleep disturbances in KCNB1-related disorders: Insights from a cohort of 78 individuals.

Epilepsia open·2026
Same author

Beyond seizures: proceedings of the ERN EpiCARE working group 18 on developmental and epileptic encephalopathies.

Epilepsy & behavior : E&B·2026
Same author

Developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep: Pathophysiological insights and treatment options.

Epilepsia·2026
Same author

Microsurgical Resection of Subependymal Giant Cell Astrocytoma: Single-Center Retrospective Analysis and Meta-Analysis.

Neurosurgery·2026
Same author

Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies.

Nature genetics·2026
Same author

Pediatric tuberous sclerosis complex: assessment of multidisciplinary follow-up in an expert center.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2026
Same journal

Surface EEG to Identify Cognitive Motor Dissociation After Acute Brain Injury.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

The Physics and Physiology of Electrical Stimulation of the Brain.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Neurophysiology in Postanoxic Encephalopathy: Pathophysiology, Prognosis, and Treatment.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

A Review on the Functional Connectivity of the Human Opercular Cortex.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Surgical Aspects of Opercular Epilepsies.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Cost-Effectiveness of EEG Monitoring in Hypoxic-Ischemic Brain Injury After Cardiac Arrest.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
See all related articles

Epileptic encephalopathies involve neurologic decline due to seizures. Treatment varies by syndrome, with valproate often preferred for infants and children when a diagnosis is uncertain.

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Epileptology

Background:

  • Epileptic encephalopathies are characterized by neurological deterioration linked to epileptic activity.
  • This deterioration can stem from frequent seizures or continuous interictal activity.
  • Various syndromes manifest differently across age groups, from infancy to school age.

Purpose of the Study:

  • To outline the spectrum of epileptic encephalopathies.
  • To describe the key features and age-specific presentations of these conditions.
  • To highlight diagnostic and therapeutic considerations.

Main Methods:

  • Review of epileptic encephalopathy classifications and associated syndromes.
  • Description of clinical manifestations, including seizure types and neurological deficits.

Related Experiment Videos

  • Discussion of diagnostic challenges and treatment strategies.

    • Main Results:

    • Syndromes like Dravet syndrome, Ohtahara syndrome, West syndrome, and Lennox-Gastaut syndrome are defined by specific seizure patterns and developmental impacts.
    • Rasmussen syndrome involves partial seizures contributing to neurological decline.
    • Subcontinuous paroxysmal interictal activity is a hallmark in neonatal and infantile forms.

    Conclusions:

    • Epileptic encephalopathies represent a group of severe epilepsy syndromes with significant neurological consequences.
    • Accurate diagnosis is crucial as treatment strategies differ significantly among syndromes.
    • Valproate is recommended as a preferred initial treatment in uncertain cases, especially in infants and children, to avoid drug-induced worsening.