Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional antibiotic prophylaxis in elbow surgery.

Bruce S Miller1, Wade P Harper, Jeffrey S Hughes

  • 1University of Michigan Sports Medicine Program, Department of Orthopaedic Surgery, University of Michigan, ann Arbor, MI 48106-0391, USA.

Journal of Shoulder and Elbow Surgery
|January 22, 2004
PubMed
Summary

Regional antibiotic prophylaxis for elbow surgery significantly increases antibiotic concentrations in bone and fat tissue compared to standard systemic delivery. This method may reduce the risk of surgical site infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone Healing Response of Two Different Silicate-Containing Calcium Phosphate Synthetic Bone Grafts in a Rabbit Femoral Critical-Sized Defect Model.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same author

Cost-Effectiveness of 3D-Printed Patient-Specific Versus Off-the-Shelf Interbody Cages in Lumbar Spinal Fusion: A Markov Model Cost-Utility Analysis.

Journal of market access & health policy·2026
Same author

The Effect of Variable-Pitch Headless Compression Screws and Cortical Screws on Interfragmentary Compression: An In Vitro Polyurethane Foam Block Model.

Animals : an open access journal from MDPI·2026
Same author

Ex Vivo Pullout Strength of Locking and Cortical Screws in the Femur and Tibiotarsus of the Pekin Duck (<i>Anas platyrhynchos domesticus</i>).

Journal of avian medicine and surgery·2026
Same author

Augmentation of a rotator cuff tendon repair using a bioinductive biocomposite scaffold in an ovine infraspinatus model.

Journal of shoulder and elbow surgery·2025
Same author

Preclinical Evaluation of Synthetic Bone Graft Materials in an Instrumented Sheep Posterolateral Lumbar Spinal Fusion Model.

Clinical spine surgery·2025

Area of Science:

  • Orthopedic Surgery
  • Infectious Disease Prevention
  • Pharmacokinetics

Background:

  • Surgical site infections are a significant concern in orthopedic procedures.
  • Systemic antibiotic prophylaxis is standard but may not achieve optimal tissue concentrations.
  • Effective antibiotic delivery is crucial for preventing perioperative infections in elbow surgery.

Purpose of the Study:

  • To describe a regional antibiotic prophylaxis technique for elbow surgery.
  • To compare tissue antibiotic concentrations achieved by regional versus systemic prophylaxis.
  • To evaluate the safety and efficacy of regional antibiotic delivery.

Main Methods:

  • Bone and fat samples were collected from patients undergoing elective elbow surgery with regional antibiotic prophylaxis.

Related Experiment Videos

  • Antibiotic concentrations in tissue samples were measured.
  • A comparative group received standard systemic intravenous prophylaxis for shoulder surgery, with tissue samples analyzed similarly.

    • Main Results:

    • Mean tissue antibiotic concentrations were substantially higher with regional prophylaxis (bone: 1484 µg/g; fat: 1422.7 µg/g) compared to systemic prophylaxis (bone: 35.8 µg/g; fat: 10.7 µg/g).
    • The differences in tissue antibiotic concentrations were statistically significant (P < .05).
    • No adverse effects were reported with the regional antibiotic delivery method.

    Conclusions:

    • Regional antibiotic prophylaxis in elbow surgery yields significantly higher tissue antibiotic concentrations than systemic prophylaxis.
    • This technique offers a promising strategy for enhancing infection control in elbow surgeries.
    • Regional delivery may represent a safer and more effective approach to antibiotic prophylaxis in this surgical context.