Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclin E expression in papillary thyroid carcinoma: relation to staging.

Jan Brzeziński1, Adam Migodziński, Aleksandra Gosek

  • 1Department of Endocrinological and General Surgery, Institute of Endocrinology, Medical University of Łódź, Łódź, Poland. mdedecjus@poczta.wp.pl

International Journal of Cancer
|January 22, 2004
PubMed
Summary

Cyclin E expression is common in papillary thyroid carcinoma (PTC) and linked to advanced disease. High cyclin E levels may serve as a new prognostic marker for PTC patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of Intraoperative Neuromonitoring in Thyroid Surgery in Poland - Current Status and Prospects for Development.

Polski przeglad chirurgiczny·2026
Same author

Contemporary management of radioiodine-refractory follicular thyroid carcinoma: insights from three decades of survival.

Endokrynologia Polska·2026
Same author

International expert consensus on thermal ablation for benign thyroid nodules (2025 Edition).

International journal of surgery (London, England)·2026
Same author

Castleman disease mimicking prostate cancer metastasis: diagnostic implications of [68Ga]Ga-PSMA-11 PET/CT.

Nuclear medicine review. Central & Eastern Europe·2025
Same author

Dosimetry-guided peptide receptor radionuclide therapy in neuroendocrine tumors: interim safety analysis of the DUONEN trial.

Frontiers in endocrinology·2025
Same author

International Consensus on the Requirements for Definitions of Complete Remission and Recurrence of Differentiated Thyroid Cancer: a Delphi Study (ICON-DTC).

European journal of endocrinology·2025

Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Background:

  • Cyclin E is crucial for cell cycle regulation and implicated in cancer development.
  • The role of cyclin E in papillary thyroid carcinoma (PTC) has not been previously established.

Purpose of the Study:

  • To investigate the expression of cyclin E in PTC.
  • To analyze the correlation between cyclin E expression and clinicopathological features of PTC.

Main Methods:

  • Immunohistochemistry was used to assess cyclin E expression in 41 PTC samples.
  • Staining results were graded and correlated with tumor stage (pT1a-pT4) and lymph node metastasis.

Main Results:

  • Cyclin E was expressed in 75.6% of PTCs, with higher prevalence (90.4%) in tumors staged higher than pT1a.

Related Experiment Videos

  • Papillary microcarcinomas (PMCs) showed significantly lower cyclin E expression compared to larger PTCs.
  • A positive correlation was found between cyclin E staining index and the T factor of PTC staging.
  • All lymph node metastases were associated with cyclin E expression, and most with overexpression.

    • Conclusions:

    • Cyclin E expression is frequent in PTC and associated with tumor progression and metastasis.
    • Cyclin E may play a significant role in PTC oncogenesis and biological behavior.
    • Elevated cyclin E levels could potentially serve as a novel prognostic biomarker for PTC.