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Status epilepticus in a population-based Virginia twin sample.

Linda A Corey1, John M Pellock, Robert J DeLorenzo

  • 1Virginia Institute for Psychiatric and Behavior Genetics, Department of Human Genetics, Virginia Commonwealth University, Richmond, Virginia 23298-0003, USA. corey@mail2.vcu.edu

Epilepsia
|January 24, 2004
PubMed
Summary

This study estimates the occurrence of status epilepticus (SE) in twins, finding a genetic link. Further research is needed to understand the genetic contribution to SE risk.

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Area of Science:

  • Neurology
  • Genetics
  • Epidemiology

Background:

  • Status epilepticus (SE) is a neurological emergency with significant morbidity.
  • Understanding the frequency and risk factors for SE is crucial for public health.
  • Twin studies are valuable for disentangling genetic and environmental influences on disease risk.

Purpose of the Study:

  • To determine the incidence of first-occurrence status epilepticus (SE) in a population-based twin cohort.
  • To investigate the role of genetic factors in the susceptibility to SE.
  • To characterize the clinical features of SE in the studied population.

Main Methods:

  • A population-based sample of 13,506 unselected Virginia-born twin pairs was ascertained.
  • Medical records and interviews were used to validate seizure and SE history in twins aged 2-75 years.

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  • Proband-wise concordance rates were calculated for monozygotic (MZ) and dizygotic (DZ) twins.

    • Main Results:

    • Among 332 pairs with verified seizure history, 70 twins (18.4%) experienced SE.
    • The incidence of first SE was estimated at 309 per 100,000 twins.
    • The proband-wise concordance rate for SE was 0.31 in MZ twins, suggesting a genetic contribution.

    Conclusions:

    • This study provides an incidence estimate for SE in a defined twin population.
    • Findings support a significant genetic contribution to the risk of developing SE.
    • Further research into specific genetic factors influencing SE susceptibility is warranted.