Influence of calcium removal from bath solution on isolated rat duodenum contractions

¹Department of Physiology, Erciyes University, Medical Faculty, Kayser, Turkey.

Indian Journal of Physiology and Pharmacology

|July 1, 1992

Abstract:

In this study whether extracellular Ca++ is essential to produce an increase of tension of isolated rat duodenum by ACh, 5-HT, AVP and KCl-, was examined. KCl- and AVP-evoked contractions were almost totally prevented by Ca++ removal from bath solution. The increase of tension of isolated duodenum caused by ACh or 5-HT was totally prevented after adding nifedipine, a Ca++ channel blocker, into Ca free solution. Our results suggest that ACh or 5-HT utilizes intracellular as well as extracellular sources of Ca++ to produce contraction in rat duodenum, whereas AVP-or KCl evoked contraction was mainly due to influx of Ca from extracellular sources.

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Abstract:

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