Related Experiment Video
Updated: Aug 8, 2026

07:43
Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
Published on: August 5, 2021
Hypertensive retinopathy and choroidopathy in a cat
András M Komáromy1, Stacy E Andrew, Heidi M Denis
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0126, USA. komaromy@vet.upenn.edu
Veterinary Ophthalmology
|January 24, 2004
Summary
Amlodipine besylate successfully treated vision loss in a cat with hypertensive retinopathy. This L-type calcium channel blocker lowered blood pressure, restoring sight and improving retinal function.
Area of Science:
- Veterinary Ophthalmology
- Cardiology
- Internal Medicine
Background:
- Systemic hypertension is a common condition in older cats, often leading to ocular complications.
- Hypertensive retinopathy and choroidopathy can cause significant vision impairment, including retinal detachment.
- Early diagnosis and management are crucial for preserving vision in affected animals.
Observation:
- A 17-year-old Domestic Short-haired cat presented with bilateral hypertensive retinopathy and choroidopathy, complicated by bullous retinal detachment.
- The etiology of the systemic hypertension remained idiopathic (unknown).
- Ophthalmic examination revealed severe retinal changes consistent with sustained high blood pressure.
Findings:
- Oral administration of amlodipine besylate, a potent L-type calcium channel blocker, effectively reduced the cat's blood pressure.
- Following blood pressure normalization, the cat experienced a significant improvement in vision.
- Electroretinography confirmed enhanced retinal function and recovery after treatment.
Implications:
- Amlodipine besylate is an effective therapeutic option for managing systemic hypertension and associated ocular disease in cats.
- Prompt treatment of hypertensive retinopathy can lead to vision restoration and improved quality of life.
- This case highlights the importance of blood pressure monitoring and ophthalmic screening in feline patients.
Related Concept Videos
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

