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Related Experiment Videos

Human circoviruses.

Philippe Biagini1

  • 1Unité des Virus Emergents, EA 3292, Laboratoire de Virologie Moléculaire, Etablissement Français du Sang Alpes-Méditerranée et Faculté de Médecine, 149, Boulevard Baille, 13005 Marseille, France. pbiagini-ets-ap@gulliver.fr

Veterinary Microbiology
|January 27, 2004
PubMed
Summary
This summary is machine-generated.

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TT virus (TTV) and TTV-like mini virus (TLMV) are common human circoviruses with high genetic variability. While infections are often asymptomatic, their association with specific pathologies remains possible.

Area of Science:

  • Virology
  • Human infectious diseases

Background:

  • TT virus (TTV) and TTV-like mini virus (TLMV) are the first identified human circoviruses.
  • They exhibit no significant sequence homology with known animal circoviruses.
  • These viruses are prevalent in various human body fluids.

Purpose of the Study:

  • To summarize the characteristics of TTV and TLMV.
  • To discuss their transmission routes and genetic variability.
  • To highlight their unique transcription profile and potential pathological associations.

Main Methods:

  • Literature review and analysis of existing data on TTV and TLMV.
  • Comparative sequence homology analysis with animal circoviruses.
  • Examination of reported detection methods and prevalence studies.

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  • Analysis of transcription profiles and RNA splicing patterns.

    • Main Results:

    • TTV and TLMV are widespread human circoviruses with high genetic diversity.
    • Transmission occurs through parenteral, saliva droplet, and fecal-oral routes.
    • Co-infections with different viral strains are common.
    • A unique transcription profile involving multiple splicing events has been identified.

    Conclusions:

    • TTV and TLMV represent a significant group of human circoviruses.
    • Despite asymptomatic infections, potential links to pathologies cannot be excluded.
    • Further research is needed to fully understand their clinical significance.