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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
Human circoviruses
1Unité des Virus Emergents, EA 3292, Laboratoire de Virologie Moléculaire, Etablissement Français du Sang Alpes-Méditerranée et Faculté de Médecine, 149, Boulevard Baille, 13005 Marseille, France. pbiagini-ets-ap@gulliver.fr
Abstract:
TT virus (TTV) and TTV-like mini virus (TLMV) represent the first described human circoviruses. They do not show significant sequence homology with any other animal circovirus identified to date. They are both detected with high prevalences in various body fluids. The spread mode may include the parenteral way, the transmission by saliva droplets and the fecal-oral route. Genetic variability within a viral group is high and the co-infection by distinct viral strains is common in a given individual. The description of several messenger RNAs obtained after multiple splicing revealed a specific transcription profile. Despite apparent asymptomatic infections, the possible association of variants of TTV and TLMV with a given pathology cannot be formally ruled out.
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