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TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells
Masayuki Inoue1, Haifeng Zhai, Hayato Sakazaki
1Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. inoue@ykbsc.chem.tohoku.ac.jp
Bioorganic & Medicinal Chemistry Letters
|January 27, 2004
Abstract:
TMC-95A has been characterized as a potent proteasome inhibitor that binds to enzymes non-covalently at low nanomolar concentrations. Herein, the neuritogenic activity of TMC-95A in PC12 rat pheochromocytoma cells is reported for the first time. TMC-95A induced a positive neurite initiation of PC12 cells at concentration ranging from 1 to 20 microM.
