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[Bone mineral density in school age children born preterm ]
Aída Milinarsky1, Sylvia Fischer, Vinka Giadrosich
1Departamentos de Pediatría y Medicina, Facultad de Medicina, Universidad de Valparaíso, Chile. pediatria@uv.cl
Revista Medica De Chile
|January 28, 2004
Summary
Children born preterm have lower bone mineral density at 5-7 years old. Bone mineral density in these children correlates with insulin growth factor 1 (IGF-1).
Area of Science:
- Pediatric endocrinology
- Bone health research
- Neonatal follow-up studies
Context:
- Bone mineral density (BMD) normalization timing in preterm infants is not well-established.
- Preterm birth can impact long-term skeletal development.
- Understanding skeletal outcomes in preterm children is crucial for growth monitoring.
Purpose:
- To determine if bone mineral density (BMD) normalizes by 5 to 7 years of age in children born preterm.
- To compare BMD in preterm children versus term-born controls.
- To investigate factors associated with BMD in this cohort.
Summary:
- A study of 26 preterm infants and 105 term controls aged 5-7 years found significantly lower bone mineral density (BMD) in the preterm group.
- BMD in preterm children was 0.273 +/- 0.01 g/cm2 compared to 0.302 +/- 0.01 g/cm2 in term controls (p < 0.001).
- A positive correlation was observed between bone mineral density and insulin growth factor 1 (IGF-1) levels (r = 0.49, p = 0.01).
Impact:
- Preterm infants exhibit reduced bone mineral density (BMD) up to 7 years of age.
- Insulin growth factor 1 (IGF-1) is a potential biomarker for bone health in preterm children.
- Findings highlight the need for continued monitoring of bone health in individuals born preterm.