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Brain activation patterns associated with working memory in relapsing-remitting MS.

H A Wishart1, A J Saykin, B C McDonald

  • 1Department of Psychiatry, Dartmouth Medical School/Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756-0001, USA.

Neurology
|January 28, 2004
PubMed
Summary
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Multiple sclerosis (MS) alters brain activity during working memory tasks. Patients with mild relapsing-remitting MS showed different activation patterns compared to healthy individuals.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Medical Imaging

Background:

  • Multiple sclerosis (MS) is characterized by altered brain activation patterns during various tasks.
  • These alterations involve decreased activation in typical functional networks and increased activation in other brain regions.

Purpose of the Study:

  • To investigate if working memory brain activation patterns are affected in individuals with MS.
  • To compare working memory task performance and associated brain activity between MS patients and healthy controls.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed to examine working memory circuitry activation.
  • An n-back task was administered to adults with mild relapsing-remitting MS (n=10) and healthy controls (n=10).

Related Experiment Videos

Main Results:

  • Significant group differences in brain activation were observed under both low- and high-demand working memory conditions (p < 0.001).
  • MS patients exhibited reduced activation in core prefrontal and parietal working memory regions compared to controls.
  • Conversely, patients showed increased activation in regions both within and outside the typical working memory network, including medial frontal, cingulate, parietal, middle temporal, and occipital areas.

Conclusions:

  • Individuals with mild relapsing-remitting MS display modified brain activation patterns during working memory tasks.
  • These shifts in activation occur within and extend beyond the established neural circuitry of working memory.