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MR flow mapping of dobutamine-induced changes in diastolic heart function
Bernard P Paelinck1, Hildo J Lamb, Jeroen J Bax
1University Hospital Antwerp, Antwerp, Belgium. Bernard.paelinck@uza.be
Journal of Magnetic Resonance Imaging : JMRI
|January 28, 2004
Summary
Magnetic resonance (MR) flow mapping effectively measures left ventricular filling changes during beta-adrenergic stimulation, showing increased stroke volume and filling rates. This technique aids in assessing myocardial relaxation dynamics.
Area of Science:
- Cardiovascular Imaging
- Physiology
- Pharmacology
Background:
- Assessing left ventricular filling dynamics is crucial for understanding cardiac function.
- Beta-adrenergic stimulation alters cardiac performance, necessitating accurate measurement techniques.
Purpose of the Study:
- To evaluate the efficacy of MR flow mapping in quantifying left ventricular filling changes.
- To assess the impact of beta-adrenergic stimulation on diastolic function using MR flow mapping.
Main Methods:
- Utilized conventional free-breathing fast-field echo (FFE) MR sequence with high spatial (2.7 x 2.2 mm) and temporal (22 msec) resolution.
- Measured mitral inflow in 10 healthy volunteers under basal conditions and during dobutamine infusion (20 microg/kg/minute).
Main Results:
- Stroke volume significantly increased from 99 mL to 114 mL (P < 0.05).
- Early (E) and atrial (A) peak filling rates showed significant increases (P < 0.05).
- Observed increases in E acceleration and A deceleration peaks, indicative of facilitated myocardial relaxation.
Conclusions:
- Conventional free-breathing FFE MR flow mapping is capable of measuring alterations in left ventricular filling.
- The technique successfully demonstrated the effects of beta-adrenergic stimulation on diastolic function and myocardial relaxation.