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Related Experiment Videos

Bone marrow diffusion in osteoporosis: evaluation with quantitative MR diffusion imaging.

David K W Yeung1, Samuel Y S Wong, James F Griffith

  • 1Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong, China. dkyeung@cuhk.edu.hk

Journal of Magnetic Resonance Imaging : JMRI
|January 28, 2004
PubMed
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Quantitative MR diffusion imaging reveals decreased diffusion in vertebral bone marrow of postmenopausal women with osteoporosis. This finding suggests fatty marrow accumulation, making diffusion imaging a potential tool for osteoporosis research.

Area of Science:

  • Radiology and Imaging Science
  • Bone Metabolism and Osteoporosis Research
  • Biophysics of Diffusion Processes

Background:

  • Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk.
  • Fatty infiltration of bone marrow is associated with decreased bone quality in osteoporosis.
  • Quantitative magnetic resonance (MR) imaging offers a non-invasive method to assess tissue characteristics.

Purpose of the Study:

  • To quantify vertebral body marrow diffusion using MR diffusion imaging.
  • To investigate differences in marrow diffusion between postmenopausal women with osteoporosis and premenopausal controls.

Main Methods:

  • Echo-planar diffusion imaging at 1.5 T was performed on 44 postmenopausal women (mean age 70) and 20 premenopausal controls (mean age 28).

Related Experiment Videos

  • Various b values were used to calculate extravascular diffusion (D) and apparent diffusion coefficient (ADC).
  • BMD was assessed using dual-energy x-ray absorptiometry (DXA).

    • Main Results:

    • Both D and ADC values showed a trend of decreasing with lower BMD.
    • Mean D values were significantly lower in osteoporotic women compared to controls.
    • Mean ADC values were significantly lower in subjects with reduced BMD and normal BMD compared to controls.

    Conclusions:

    • Decreased D and ADC values reflect fatty bone marrow accumulation in osteoporosis.
    • MR diffusion imaging shows promise as a tool for studying osteoporosis.
    • Quantitative diffusion parameters may help differentiate bone marrow states related to osteoporosis.