Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Unilateral multicentric breast cancer.

Josip Fajdić1, Damir Buković, Damir Gugić

  • 1Department of Surgery, General Hospital Pozega, Pozega, Croatia.

Collegium Antropologicum
|January 30, 2004
PubMed
Summary

Unilateral multicentric breast cancer (UMBC) shows similar prognosis to monocentric breast cancer (MOBC), especially in early stages. Multicentricity does not significantly increase the risk of poor prognosis in these patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foreign body ingestions in children and adolescents: A position paper of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) endoscopy special interest group.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Safety of infant milks: Contamination with cereulide. A commentary by ESPGHAN (European Society for Paediatric Gastroenterology, Hepatology, and Nutrition).

Journal of pediatric gastroenterology and nutrition·2026
Same author

Gastric myoelectrical activity and autonomic dysfunction in children with IBD and IBS: An electrogastrographic and autonomic correlation study.

Autonomic neuroscience : basic & clinical·2026
Same author

Growth trajectories of children with short bowel syndrome during the first year of teduglutide treatment.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Histological activity predicts relapse in pediatric ulcerative colitis despite mucosal healing: a multicenter study from the pediatric IBD Porto group of ESPGHAN.

Journal of Crohn's & colitis·2026
Same author

Subclinical Respiratory Involvement in Children with Inflammatory Bowel Disease: FeNO Elevation in Active Disease.

Children (Basel, Switzerland)·2026

Area of Science:

  • Oncology
  • Surgical Pathology
  • Clinical Breast Cancer Research

Background:

  • Unilateral multicentric breast cancer (UMBC) is a subtype of breast cancer characterized by multiple tumor foci within the same breast.
  • Understanding the clinical characteristics and prognostic implications of UMBC is crucial for effective patient management.

Purpose of the Study:

  • To explore the clinical characteristics of UMBC based on aggressiveness, survival rates, disease-free periods, and local recurrence.
  • To compare the prognosis of UMBC with monocentric breast cancer (MOBC).

Main Methods:

  • Retrospective analysis of 296 women with breast cancer surgically treated between 1990 and 2001.
  • Histopathological confirmation of UMBC in 29 patients, with defined criteria for multicentricity.

Related Experiment Videos

  • Kaplan-Meier analysis to assess survival rates and disease-free periods.

    • Main Results:

    • UMBC was diagnosed in 9.8% of patients, with an average age of 63.4 years.
    • A high rate of axillary lymph node involvement (68.9%) was observed.
    • Local recurrence was low (10.3%), and a five-year disease-free period was achieved in 82.7% of patients.
    • Survival rates were significantly lower in advanced stages (N2 grade), but multicentricity itself did not worsen the prognosis compared to MOBC, particularly in lower tumor stages (I or II).

    Conclusions:

    • Multicentricity in breast cancer does not appear to significantly increase the risk of a poor prognosis, especially in early-stage disease.
    • The prognostic outcomes for UMBC are comparable to MOBC, particularly when considering tumor stage and axillary involvement.
    • Further research may be warranted to refine treatment strategies for UMBC.