Related Experiment Videos
Alterations in resistin expression after thermal injury
Mohan R K Dasu1, Lavenia LaGrone, William J Mileski
1Department of Surgery, University of Texas Medical Branch, Galveston, 77555, USA.
The Journal of Trauma
|January 30, 2004
Summary
Burn injury increases resistin, a hormone linked to insulin resistance. This study in mice suggests resistin plays a role in metabolic changes following severe burns.
Area of Science:
- Metabolic response to injury
- Endocrinology
- Burn pathophysiology
Background:
- Burn injuries can alter resistin expression, potentially causing metabolic disturbances.
- Investigating the link between resistin and postburn metabolic derangements.
Purpose of the Study:
- To examine resistin gene expression and serum protein levels in burned mice.
- To assess the relationship between resistin and glucose levels post-burn.
Main Methods:
- Burned and sham-burned mice were analyzed at various time points (2, 4, 24, 48 hours).
- Resistin gene expression was measured using real-time RT-PCR in gonadal fat tissue.
- Serum resistin, insulin, and glucose levels were quantified.
Main Results:
- Burned mice showed increased resistin gene expression and elevated serum resistin levels.
- These increases in resistin correlated with relative insulin resistance.
- Significant differences were observed between burned and sham-burned groups.
Conclusions:
- Resistin may play a significant role in the metabolic response to burn injury.
- Findings suggest resistin as a potential therapeutic target for managing postburn metabolic complications.