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Updated: Aug 29, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
Gonadotropin releasing hormone antagonists and cryopreservation outcome: a review
N Nikolettos1, B Asimakopoulos, M Simopoulou
1Laboratory of Reproductive Physiology-IVF, Faculty of Medicine, Democritus University of Thrace, 68100, Dragana, Alexandroupolis, Greece. nnikolettos@hotmail.com
Review:
The outcome of freeze-thaw cycles with pronuclear stage oocytes or embryos, derived from collecting cycles stimulated with gonadotropin-releasing hormone (GnRH)-antagonists' protocols, was reviewed.
Conclusion:
The viability of cryopreserved pronuclear stage oocytes and embryos, the quality of transferred embryos and the pregnancy rates of the freeze-thaw cycles seem to be satisfactory regardless of the type and dose of GnRH-antagonist.
