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A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
Soft tissue and joint infection
1Department of Radiology, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK. david.wilson@radiology.oxford.ac.uk
Abstract:
Soft tissue infection may be acute or chronic and may be introduced by the haematogenous route, or by inoculation, including surgical infection, or spread from other areas. The spectrum of infecting organism differs in primary infection, in immunodeficiency or when foreign bodies, including prostheses, are present. Bacterial infections are usually more rapid than those due to fungi or atypical organisms. Inflammation usually begins as cellulitis, proceeding through necrosis to cavitation and abscess formation, sometimes complicated by haemorrhage. Imaging, apart from MRI in selected cases, is rarely helpful in the early stages, but early diagnosis of pyomyositis and necrotizing fasciitis is mandatory. When infection is established, US, CT and MRI all have individual value in diagnosis, including biopsy, and in directing therapy, including percutaneous or surgical drainage or debridement. Both MRI and CT are best suited to monitoring progress. Septic arthritis presents as rapidly progressive, destructive arthritis, and early diagnosis is essential to prevent long-term morbidity. Ultrasound offers the best method of detecting early joint effusion and synovial thickening, but aspiration is usually required for diagnosis. In more advanced stages CT is valuable for revealing destructive changes, and MRI for documenting intra-articular changes and detecting inflammation in surrounding bone.
Insights
Diagnosing soft tissue infections and septic arthritis early is crucial. Imaging like MRI and CT aids in diagnosis and guiding treatment for these conditions.
Area of Science:
- Radiology
- Infectious Diseases
- Orthopedic Surgery
Background:
- Soft tissue infections can be acute or chronic, originating from various routes like hematogenous spread or inoculation.
- The causative organisms and disease progression vary based on host factors and the presence of foreign bodies.
- Early recognition of aggressive infections like pyomyositis and necrotizing fasciitis is critical.
Purpose of the Study:
- To review the role of imaging in diagnosing and managing soft tissue infections and septic arthritis.
- To highlight the utility of different imaging modalities at various stages of these conditions.
Main Methods:
- Discussion of imaging techniques including Ultrasound (US), Computed Tomography (CT), and Magnetic Resonance Imaging (MRI).
- Emphasis on the diagnostic value of imaging for identifying infection, guiding biopsies, and directing therapeutic interventions like drainage.
- Assessment of imaging's role in monitoring treatment response.
Main Results:
- Imaging is often non-specific in early soft tissue infection stages, but crucial once established.
- US is optimal for early septic arthritis detection (effusion, synovial thickening); aspiration is key for diagnosis.
- CT and MRI are valuable for assessing advanced septic arthritis, soft tissue abscesses, and guiding debridement or drainage.
Conclusions:
- Prompt diagnosis of soft tissue infections and septic arthritis is essential to prevent severe morbidity.
- A combination of clinical assessment and appropriate imaging modalities is vital for effective management.
- Imaging plays a significant role in diagnosis, treatment guidance, and monitoring of musculoskeletal infections.
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