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The autonomic nervous system in systemic sclerosis. A review
Luca Bertinotti1, Stefania Bracci, Francesca Nacci
1Department of Medicine, Villa Monna Tessa, Viale G. Pieraccini 18, 50139, Florence, Italy.
Clinical Rheumatology
|January 30, 2004
Summary
Systemic sclerosis significantly affects the autonomic nervous system. This review explores its major manifestations and pathogenesis theories, highlighting it as an underestimated target.
Area of Science:
- Autonomic Nervous System Research
- Systemic Sclerosis Pathogenesis
Background:
- Systemic sclerosis (SSc) is a complex autoimmune disease.
- Autonomic nervous system (ANS) dysfunction is increasingly recognized in SSc.
Purpose of the Study:
- To review the major manifestations of autonomic nervous system involvement in systemic sclerosis.
- To reconsider the pathogenesis theories of autonomic dysfunction in SSc.
Main Methods:
- Literature review of studies on SSc and autonomic nervous system.
- Analysis of current theories regarding autonomic nervous system involvement in SSc.
Main Results:
- Autonomic nervous system alterations are a significant, often underestimated, feature of systemic sclerosis.
- Various manifestations of autonomic dysfunction are observed in SSc patients.
Conclusions:
- The autonomic nervous system is a critical target in understanding and potentially treating systemic sclerosis.
- Further research into SSc-associated autonomic dysfunction is warranted.