Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Efficient fluoride-selective fluorescent host: experiment and theory.

Jin Yong Lee1, Eun Jin Cho, Shaul Mukamel

  • 1Department of Chemistry, Chonnam National University, 300 Yongbong-Dong, Bugku, Gwangju, 500-757, Korea. jinyong@chonnam.ac.kr

The Journal of Organic Chemistry
|January 31, 2004
PubMed
Summary

Researchers developed a novel naphthalene derivative that uniquely detects fluoride ions. Strong hydrogen bonding with fluoride causes a distinct spectral shift, enabling selective ion sensing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrochemical deoxygenative trifluoromethylallenylation of propargylic alcohols <i>via</i> sodium-mediated pre-association.

Chemical science·2026
Same author

Comparative Preclinical Evaluation of BIX-01294 and UNC0642 as EHMT2-Targeting Anticancer Agents.

Cancers·2026
Same author

Visible-Light Photoredox Synthesis of Chroman-4-ones from Sulfoxonium Ylides.

Organic letters·2026
Same author

Ni-Catalyzed Cyclotrimerization of Unactivated Internal Alkynes: Ligand-Dependent Regioselectivity.

The Journal of organic chemistry·2025
Same author

Nickel-Catalyzed 3,2-Hydroallylation of 1,1-Disubstituted Allenes with Vinyl Cyclopropanes: Access to Functionalized 1,4-Dienes.

Organic letters·2025
Same author

Reductive Amination of Carboxylic Acids via Nickel(II) Catalysis: A Ligand-Tuned Strategy for C-N Bond Formation.

The Journal of organic chemistry·2025

Area of Science:

  • Supramolecular Chemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Development of selective chemosensors for halide ions is crucial for environmental and biological monitoring.
  • Naphthalene derivatives offer versatile platforms for designing fluorescent sensors due to their photophysical properties.

Purpose of the Study:

  • To synthesize and characterize a novel 1,8-naphthalene derivative incorporating a urea moiety.
  • To investigate the molecule's response to various halide ions, focusing on fluoride detection.
  • To elucidate the sensing mechanism using computational analysis.

Main Methods:

  • Synthesis of a 1,8-naphthalene derivative with a urea functional group.
  • Spectroscopic analysis (absorption and fluorescence) in the presence of different halide ions (F-, Cl-, Br-).

Related Experiment Videos

  • Density Functional Theory (DFT) calculations, including collective electronic oscillator (CEO) method, to analyze electronic transitions and bonding.

    • Main Results:

    • The synthesized naphthalene derivative exhibited a unique absorption and fluorescence peak shift upon interaction with fluoride ions.
    • Computational studies indicated that strong hydrogen bonding between fluoride and urea protons enhances the anionic character of urea nitrogen.
    • Fluoride selectivity was observed due to its closer approach and dynamic residence within the molecular cavity compared to other halides.

    Conclusions:

    • The novel naphthalene derivative acts as an effective fluorescent sensor for fluoride ions.
    • The sensing mechanism involves enhanced anionic character of urea nitrogen driven by specific hydrogen bonding interactions with fluoride.
    • The unique binding dynamics and electronic transitions confirm the selective detection of fluoride.