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Updated: Jan 6, 2026

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes
Published on: November 21, 2017
Reductive Amination of Carboxylic Acids via Nickel(II) Catalysis: A Ligand-Tuned Strategy for C-N Bond Formation
Gayeon Lee1, Jaehan Bae1, Kashif Ali1
1Department of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.
Abstract:
A nickel(II)-catalyzed reductive amination of carboxylic acids with amines is described, employing phenylsilane as the reductant. The reaction proceeds via an iminium ion/imine intermediate and does not require prior carboxylic acid activation. A comprehensive evaluation of ligands identified bulky trialkyl monophosphines as optimal, with tricyclohexylphosphine providing the highest yield. This ligand-controlled protocol provides direct access to diverse secondary and tertiary amines from readily available carboxylic acids, illustrating a practical approach to C-N bond formation.
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