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[Posner-Schlossman syndrome].

U Köhler1

  • 1Universitäts-Augenklinik Marburg a.d. Lahn.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|January 1, 1992
PubMed
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This study examines a patient with Posner-Schlossman syndrome, highlighting its differential diagnoses. The findings suggest that several distinct ocular conditions may represent different manifestations of a single underlying disease due to shared developmental origins.

Area of Science:

  • Ophthalmology
  • Genetics
  • Developmental Biology

Background:

  • Posner-Schlossman syndrome is characterized by recurrent acute anterior uveitis with secondary glaucoma.
  • Differential diagnoses include other causes of unilateral glaucomatocyclitic crises.
  • Axenfeld's anomaly and connective tissue disorders can present with overlapping ocular and systemic features.

Observation:

  • A 20-year-old patient presented with clinical features of Posner-Schlossman syndrome.
  • The patient also exhibited signs of Axenfeld's anomaly, a status-dysrhaphicus-like state post-atrial septal defect, and joint hypermobility.
  • Ocular examination revealed shared pathological effects on the Descemet membrane, anterior chamber angle, and iris.

Findings:

  • The clinical presentation mimicked Posner-Schlossman syndrome but included features of Axenfeld's anomaly.

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  • The patient's systemic findings, including joint hypermobility and post-surgical status, were noted.
  • Similarities in Descemet membrane, anterior chamber angle, and iris pathology were observed across Posner-Schlossman syndrome, heterochromic cyclitis, anterior-chamber cleavage syndrome, and iridocorneal-endothelial (ICE) syndrome.

    • Implications:

    • The shared mesodermal origin of affected ocular tissues suggests a unifying etiology for these conditions.
    • Posner-Schlossman syndrome, heterochromic cyclitis, anterior-chamber cleavage syndrome, and ICE syndrome may represent a spectrum of a single disease entity.
    • This perspective could refine diagnostic approaches and therapeutic strategies for these related disorders.