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Updated: Aug 29, 2026

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
Published on: February 5, 2021
The therapeutic potential of antigen-oligonucleotide conjugates
Sandip K Datta1, Kenji Takabayashi, Eyal Raz
1The Sam and Rose Stein Institute for Research on Aging, Department of Medicine, University of California-San Diego, La Jolla, California 92093-0663, USA. sdatta@ucsd.edu
Abstract:
Conjugation of protein antigen with immunostimulatory oligonucleotides creates a potent immunogen that elicits antigen-specific antibody responses, a Th1-biased cytokine profile, and CD8 cytotoxic T lymphocyte activity. The wide range of humoral and cellular immune responses induced by these conjugates suggests they can be used to create effective vaccines against infectious pathogens and tumors and to beneficially modulate the immune responses seen in allergic diseases. This review summarizes the available data on the use of antigen-oligonucleotide conjugates and discusses their potential use for the treatment of infectious, oncologic, and allergic diseases in humans.
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