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Updated: Aug 14, 2026

IgY Technology: Extraction of Chicken Antibodies from Egg Yolk by Polyethylene Glycol (PEG) Precipitation
Published on: May 1, 2011
Immunization of egg-allergic individuals with egg- or chicken-derived vaccines
John M Kelso1, John W Yunginger
1Allergy Division, Naval Medical Center San Diego, CA 92134-5000, USA. JMKelso@nmcsd.med.navy.mil
Abstract:
Viruses used in several vaccines are propagated in embryonated eggs. These vaccines contain variable quantities of residual egg or chicken proteins and pose risks when administered to egg- or chicken-sensitive persons. This article highlights differences in how vaccines are prepared, with emphasis on the quantitation of residual egg-derived protein in each vaccine. Published reports on the frequency and severity of these vaccine-induced allergic reactions are reviewed, and an algorithm is provided for the preimmunization evaluation of egg-sensitive persons.
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