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Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD
Jonathan Mill1, Sarah Curran, Sandra Richards
1Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom. j.mill@iop.kcl.ac.uk
Summary
This study investigated dopamine D5 receptor (DRD5) gene variants in attention-deficit hyperactivity disorder (ADHD). Little evidence supports DRD5
Area of Science:
- Neurogenetics
- Psychiatric Genetics
Background:
- Dopamine-related genes are implicated in attention-deficit hyperactivity disorder (ADHD) etiology.
- A microsatellite near the dopamine D5 receptor (DRD5) gene has shown prior associations with ADHD.
- Polymorphisms in the DRD5 vicinity require further investigation for their role in ADHD.
Purpose of the Study:
- To examine the association between microsatellite markers spanning the DRD5 gene region and ADHD.
- To investigate novel polymorphisms near DRD5, including a promoter repeat and a dinucleotide repeat (D4S615) 3' of DRD5.
Main Methods:
- Genotyping of three microsatellite markers across the DRD5 region in a large clinical sample.
- Association analysis of individual alleles and a global test for the D4S615 marker.
Main Results:
- No significant association was found for the previously reported DRD5 marker or a promoter repeat with ADHD.
- A significant association was observed for a specific allele of D4S615, a marker previously linked to schizophrenia.
- The global test for D4S615 did not reach statistical significance, indicating a need for replication.
Conclusions:
- The DRD5 gene region shows limited evidence for a direct role in ADHD etiology.
- The D4S615 marker warrants further investigation for its potential association with ADHD, pending replication.
- Future research should focus on replicating the D4S615 findings and exploring other genetic factors in ADHD.