Related Experiment Video
Updated: Aug 13, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Aggressive squamous cell carcinoma originating as a Marjolin's ulcer
Shawn R Sabin1, Glenn Goldstein, Howard G Rosenthal
1Dermatology and Skin Cancer Specialists, Kansas City, Missouri, USA.
Background:
Marjolin's ulcer is an epidermoid carcinoma arising in a scar or chronic wound and can have an aggressive course.
Objective:
To present a case of squamous cell carcinoma arising in a burn scar with resulting metastases and to discuss Marjolin's ulcer.
Results:
The patient continued to have further metastatic disease despite aggressive surgical treatment.
Conclusion:
In following patients with chronic ulcers and wounds, it is important to evaluate any changes immediately with biopsies and further imaging studies if indicated in order to treat effectively. Even aggressive surgical intervention will sometimes be inadequate in treating these tumors.
Related Concept Videos
Cancers Originate from Somatic Mutations in a Single Cell
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer Cell Migration through Invadopodia
Cancers Originate from Somatic Mutations in a Single Cell
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Barrett Esophagus-I: Introduction
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...

