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Microporous Annealed Particle Wound Matrix for Post-Mohs Defects: A Randomized Controlled Multicenter First-In-Human
Jennifer T Hau1, Stephanie J Martin2,3,4, Colleen A Roosa5
1Cypress Dermatology, Cypress, Texas.
Summary
A new microporous annealed particle (MAP) wound matrix is safe for post-Mohs surgery, showing reduced scarring and improved wound healing compared to standard dressings.
Area of Science:
- Dermatology
- Wound Healing
- Biomaterials
Background:
- Post-Mohs surgical wounds present challenges including pain, delayed healing, and scarring.
- Limited comparative data exists for advanced wound care biomaterials in this context.
Purpose of the Study:
- To evaluate the safety and efficacy of a flowable, synthetic microporous annealed particle (MAP) wound matrix.
- To compare the MAP matrix with a hydrocolloid dressing for post-Mohs surgical wounds.
- To explore effects on pain, wound healing, and scarring.
Main Methods:
- A multicenter randomized study involving 40 patients undergoing post-Mohs surgery.
- Application of a flowable synthetic MAP wound matrix versus a hydrocolloid dressing (control).
- Primary safety endpoint assessment with exploratory endpoints including pain, Wound Bed Score, granulation time, closure time, and scarring at 6 months.
Main Results:
- The MAP wound matrix was found to be safe, meeting the primary endpoint.
- The matrix group showed numerically lower pain scores and achieved a higher Wound Bed Score earlier.
- Significantly reduced scarring was observed in the MAP matrix group (p = .0027) compared to the control.
Conclusions:
- The microporous annealed particle (MAP) wound matrix is a safe option for post-Mohs surgical wounds.
- The MAP matrix does not impede wound healing and enhances early wound bed quality.
- This advanced wound care biomaterial offers a significant benefit in reducing scarring.