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  3. Development Of A Core Outcome Domain Set For Facial Aging.
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  3. Development Of A Core Outcome Domain Set For Facial Aging.

Related Experiment Video

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
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Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Published on: September 27, 2024

Development of a Core Outcome Domain Set for Facial Aging.

McKenzie A Dirr1, Areeba Ahmed1, Daniel I Schlessinger2,3

  • 1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

JAMA Dermatology
|June 17, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Standardized outcome measures for facial aging clinical trials are lacking. A new core outcome set (COS) with 6 domains, including patient satisfaction and treatment convenience, is recommended for future studies.

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Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry
06:26

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry

Published on: December 9, 2025

Area of Science:

  • Aesthetics and Regenerative Medicine
  • Clinical Trial Methodology
  • Dermatology

Background:

  • Clinical trials for facial aging interventions lack standardized outcome domains and measures.
  • This heterogeneity hinders direct comparison of treatments, identification of superior therapies, and development of high-quality meta-analyses.

Purpose of the Study:

  • To develop a core outcome set (COS) of essential domains for reporting in clinical trials evaluating facial aging interventions.
  • To ensure consistency and comparability in assessing the efficacy and safety of treatments for facial aging.

Main Methods:

  • Comprehensive literature search of multiple databases (PubMed/Medline, Embase, Cochrane, CINAHL) from 2005 to 2026.
  • Inclusion of randomized clinical trials and controlled clinical trials assessing facial aging interventions in human participants.
  • Utilized two rounds of Delphi surveys with patient and physician stakeholders, followed by consensus meetings, to identify key outcome domains.

    • Main Results:

    • A core outcome set (COS) comprising 6 essential domains was established.
    • The domains include: overall treatment convenience, return to normal activities, overall assessment of treatment benefit, duration of effect, adverse event severity, and patient satisfaction.

    Conclusions:

    • The recommended 6 outcome domains provide a standardized framework for future facial aging clinical trials.
    • Implementing this COS will ensure that outcomes most important to patients and clinicians are consistently measured, enhancing result comparability across studies.