Related Experiment Video
Updated: Jul 4, 2026

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
Published on: August 16, 2017
Defensins
Sunder Gidumal1, Francis Reyes Orozco1, Gabrielle Cahill1
1Department of Head and Neck Surgery, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
None:
This review summarizes current understanding of defensin peptides in skin and hair rejuvenation. It draws on preclinical animal models, mechanistic studies, and human clinical trials, including data on α-defensin and β-defensin formulations. Defensins are discussed in the context of regenerative peptides, growth factor-based cosmeceuticals, extracellular vesicles, safety, regulatory considerations, and heterochronic parabiosis. The goal is to provide facial plastic surgeons and aesthetic clinicians with a practical, evidence-based overview of defensin therapy and its potential integration into regenerative aesthetic practice.
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