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Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
09:12

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Published on: January 17, 2014

[Microbiological, clinical and epidemiological aspects of Streptococcus pneumoniae isolates recovered over two years]

M Isabel Viciana1, M Victoria García-López, Alberto Mariscal

  • 1Servicio de Microbiología. Hospital Universitario Virgen de la Victoria. Málaga. Spain. isaviciana@mixmail.com

Enfermedades Infecciosas Y Microbiologia Clinica
|February 6, 2004
PubMed
Abstract

Insights

Streptococcus pneumoniae infections, primarily non-hospital acquired, show high mortality and significant penicillin resistance. Key serotypes like 19, 3, and 6B are most frequent, with resistance linked to specific serotypes.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Epidemiology

Context:

  • Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sinusitis.
  • Penicillin resistance in pneumococci is a growing global concern.
  • This study investigates pneumococcal infections in Málaga, Spain.

Purpose:

  • To determine the epidemiology of Streptococcus pneumoniae infections.
  • To analyze antibiotic resistance patterns, particularly to penicillin.
  • To identify prevalent serotypes and their association with resistance.

Summary:

  • Over two years, 170 cases of Streptococcus pneumoniae infection were identified, predominantly non-hospital acquired (88%).
  • Mortality was 12.4%, with 45.9% of strains resistant to penicillin and 20% to cefotaxime.
  • Thirty-one serotypes were found; serotypes 19, 3, and 6B were most common in non-hospital infections, while 9V and 23F were linked to nosocomial infections. Penicillin resistance was associated with serotypes 6B, 9V, 14, 19, and 23F.

Impact:

  • Highlights the significant burden of non-hospital acquired pneumococcal infections.
  • Underscores the challenge of penicillin-resistant Streptococcus pneumoniae.
  • Informs local public health strategies and antibiotic stewardship.

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