Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cleavage furrow positioning.

Michael Glotzer¹

¹Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. mglotzer@imp.univie.ac.at

The Journal of Cell Biology

|February 6, 2004

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A key role for centralspindlin and Ect2 in the development of multicellularity and the emergence of Metazoa.

Current biology : CB·2025

Same author

A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis.

Journal of cell science·2025

Same author

Projective light-sheet microscopy with flexible parameter selection.

Nature communications·2024

Same author

Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling.

Developmental cell·2023

Same author

Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation.

eLife·2022

Same author

Small GTPases modulate intrinsic and extrinsic forces that control epithelial folding in <i>Drosophila</i> embryos.

Small GTPases·2021

Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026

Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026

Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026

Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026

Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026

Same journal

Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation.

The Journal of cell biology·2026

See all related articles

Cell division requires a cleavage furrow to divide the cytoplasm. Recent findings suggest that microtubules may regulate cleavage furrow positioning by relieving inhibitory effects during cell cycle progression.

Area of Science:

Cell Biology
Molecular Biology
Cytokinesis

Background:

Cytokinesis is the final stage of the cell cycle, involving cell division.
Cleavage furrow formation is crucial for cytokinesis, ensuring proper cell separation.
The precise positioning of the cleavage furrow is regulated by the mitotic spindle.

Purpose of the Study:

To investigate the molecular mechanisms underlying cleavage furrow positioning.
To explore the role of microtubules in regulating cleavage furrow placement during cell division.

Main Methods:

The study likely involved live-cell imaging and possibly genetic or biochemical perturbations.
Analysis focused on observing the dynamics of the cleavage furrow and microtubule interactions.

Related Experiment Videos

Main Results:

Evidence suggests that local relief from microtubule-mediated inhibition plays a role in cleavage furrow positioning.
Microtubule dynamics appear to be key regulators of where the cleavage furrow forms.

Conclusions:

Cleavage furrow positioning is a complex process influenced by microtubule activity.
Understanding these mechanisms is vital for comprehending cell cycle completion and fidelity.