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Effect of left bundle branch block on systolic and diastolic function of left ventricle in heart failure

Kurtuluş Ozdemir1, Bülent Behlül Altunkeser, Bayram Korkut

  • 1Department of Cardiology, Faculty of Medicine, Selçuk University, Konya, Turkey. kurt33@hotmail.com

Angiology
|February 5, 2004
PubMed

Insights

Left bundle branch block (LBBB) impairs diastolic function in normal subjects and exacerbates it in heart failure patients. LBBB significantly affects diastolic parameters, similar to heart failure effects.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Heart Failure Research

Background:

  • Left bundle branch block (LBBB) is a conduction abnormality that can affect cardiac function.
  • The impact of LBBB on left ventricular (LV) systolic and diastolic function, particularly in the context of heart failure, requires detailed investigation.

Purpose of the Study:

  • To investigate the effects of LBBB on LV systolic and diastolic function.
  • To compare these effects in patients with heart failure and in subjects with isolated LBBB.

Main Methods:

  • Comparative study involving three groups: heart failure with LBBB (n=36), heart failure with normal conduction (n=36), and isolated LBBB (n=41).
  • Utilized coronary angiography to calculate LV end-diastolic pressure.
  • Performed echocardiography to assess LV ejection fraction, mean rate of circumferential shortening, and various Doppler parameters of diastolic function (E/A ratio, filling velocities, relaxation times).

Main Results:

  • Patients with isolated LBBB showed altered systolic function parameters but diastolic function similar to heart failure patients with normal conduction.
  • Heart failure patients with LBBB (Group I) exhibited similar LV systolic function to heart failure patients without LBBB (Group II).
  • Significant differences in diastolic function parameters (E/A ratio, EAR, EDR, EDT, IRT, DT) were observed between Group I and Group II, indicating LBBB exacerbates diastolic dysfunction in heart failure.

Conclusions:

  • LBBB induces diastolic function impairment in individuals without heart failure, mirroring effects seen in heart failure patients.
  • LBBB significantly worsens pre-existing diastolic dysfunction in patients with heart failure.

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