Correlation Analysis Between Serum Lp-PLA2 and Platelet Activation Markers in Patients With Different Degrees of...

Coronary artery disease (CAD) is characterized by complex interactions between vascular inflammation and platelet activation. This study aimed to investigate the association between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and platelet activation markers in CAD patients with different degrees of coronary stenosis. A cross-sectional observational study was conducted among 209 patients with CAD confirmed by coronary angiography. Patients were stratified into mild, moderate, and severe stenosis groups according to Gensini score tertiles. Serum levels of Lp-PLA2, P-selectin, platelet factor 4 (PF4), and β-thromboglobulin (β-TG) were measured, and their associations were evaluated using correlation analysis and multivariable linear regression. Lp-PLA2 and platelet activation markers showed progressively higher levels in patients with more severe coronary stenosis. Significant positive correlations between Lp-PLA2 and PF4 (r = .570), P-selectin (r = .503), and β-TG (r = .450) were observed in patients with severe stenosis (all P < .001). After adjustment for cardiovascular risk factors and high-sensitivity C-reactive protein (hs-CRP), Lp-PLA2 remained independently associated with platelet activation markers. These findings indicate that circulating Lp-PLA2 levels are associated with platelet activation status in CAD, particularly among patients with severe coronary stenosis. Future prospective studies are needed to clarify the temporal relationship and clinical significance of these associations.