Related Experiment Video
Updated: Aug 17, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Human papillomavirus, p53 and cyclin D1 expression in oropharyngeal carcinoma
R V Kumar1, S S Kadkol, R Daniel
1Department of Pathology, Kidwai Memorial Institute of Oncology, India. kvijaykumar@vsnl.com
Abstract:
Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1 overexpression. There was no correlation between HPV status and either p53 or Cyclin D1 overexpression (P>0.05). These three variables also did not correlate with factors such as grade of the tumour, stage of the disease or lymph nodal metastasis at presentation.
More Related Videos
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
06:57Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Related Concept Videos
Negative Regulator Molecules
DNA Damage can Stall the Cell Cycle
Positive Regulator Molecules
Inhibition of Cdk Activity
Abnormal Proliferation
DNA Damage Can Stall the Cell Cycle