[Fourier analysis of pattern visual evoked potentials and changes of the harmonic component in longstanding optic...

To determine the clinical usefulness of Fast Fourier Transform (FFT) for the detection of abnormal pattern visual evoked potentials (P-VEPs), the P-VEPs were recorded using a checkerboard pattern (check size: 14.4') which was reversed ranging from 4 to 16 per second. Fourteen eyes of 7 patients with longstanding optic neuritis and 15 eyes of age-matched normal controls were examined. Means and the standard deviation of the square root of the FFT power as a function of spectral frequency (1.953 x fHz, f = 1-17) were calculated and statistically significant levels between the two groups were studied for each reversal rate. When the reversal rate was more than 8/sec, The 1st or 2nd harmonic components decreased significantly in optic neuritis and the significant levels (p) of the 1st harmonic component were lower than that (p) of 2nd or 3rd harmonic component. When the reversal rate was 6/sec, the 1st and 2nd harmonic components decreased significantly and 1st harmonic component had the same level of significance as the 2nd harmonic component. When the reversal rate was 4/sec, the 2nd, 3rd, 5th and 6th harmonic components decreased significantly but 1st harmonic component did not. The level of significance of the 3rd harmonic component was the lowest followed by that of 2nd harmonic component.(ABSTRACT TRUNCATED AT 250 WORDS)